Medical Ultrasound Imaging
Thursday, 2 May 2024
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Targeted ultrasound contrast agents provide advantages compared with usual microbubble blood pool agents. The goal of targeted ultrasound contrast agents is to significantly and selectively enhance the detection of a targeted vascular site. Tissue-specific ultrasound contrast agents improve the image contrast resolution through differential uptake. Targeted drug delivery via contrast microbubbles is another contrast media concept and provides the potential for earlier detection and characterization of disease. Targeted contrast imaging provides a higher sensitivity and specificity than obtained with a nontargeted contrast agent. The detection of disease-indicative molecular signatures may allow early assessment of pathology on a molecular level. Molecular imaging should be an efficient and less invasive technique to obtain three-dimensional localization of pathology. Ultrasound agents typically remain within the vascular space, and therefore possible targets include molecular markers on thrombus, endothelial cells, and leukocytes. Targeted contrast agents permit noninvasive detection of thrombus, cancer, inflammation, or other sites where specific integrins or other adhesion molecules are expressed. Adhesion molecules such as monoclonal antibodies, peptides, asialoglycoproteins, or polysaccharides are incorporated into the shell of the microbubble or liposome. After injection into the bloodstream, the targeted agent accumulates via adhesion receptors at the affected site, enhancing detection with an ultrasound system. See also Acoustically Active Lipospheres, and Tissue-Specific Ultrasound Contrast Agent. • View NEWS results for 'Targeted Contrast Imaging' (1).   Further Reading: News & More:
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